COURSE DESCRIPTIONS
PHOL 430
Advanced Structural Biology I (3)
Paul Carey 368.0031
Provides students with an in-depth introduction to biophysical techniques used to quantify macromolecular structures. A major part of the course will deal with the use of nuclear magnetic resonance to derive 3-D structures of macromolecules in solution. Other topics include electron spin resonance, absorption, fluorescence and circular dichroism spetros copies, Raman and infrared spectroscopies and methods used in modeling. Taken with "Advanced Methods in Structural Biology II". This course will provide an extensive overview for graduate students specializing in structural biology. The course will be mostly lecture based. This course is cross-listed with CHEM 430, PHRM 430, and BIOC 430.
Thomas Nosek 216-368-3242
This course provides knowledge regarding cell structure and function, chiefly in mammalian cells but also in relevant model systems. The basic structure of the cell is discussed, as are various systems that regulate this structure. Topics to be covered include DNA transcription, translation and protein synthesis, intracellular transport, cell interaction with the external environment, cell cycle regulation, cell death and differentiation, signal transduction, and cell specialization and organization into tissues. The course emphasizes lectures and problem-based discussions with an emphasis on faulty-directed student self-learning. The major goals of this course are to provide students with a working knowledge of the cell to facilitate understanding of the scientific literature, and to familiarize students with current techniques in cell biology. (3 credits - twice weekly - 1.5 hr/session)
Permission of instructor required.
PHOL 451
Independent Study in Physiology (credit as arranged)
Staff
A guided program of study using physiology textbooks, research reviews, and original research articles. An independent laboratory research project may also be included. (1-36 credits)
Patrick Wintrode 216-368-3178
The goal of this course is to provide a basic working knowledge of protein structure/function and molecular biology. The course begins with a discussion of protein structure and enzyme catalysis followed by protein purification and characterization. The course then addresses concepts relating to the application of modern molecular biology techniques. Students are taught how to clone genes and use these clones in animals-and cell-based studies. The overall goal is to provide students with an understanding of proteins and genetic approaches that can be used in experimental work and to facilitate comprehension of the scientific literature. (3 credits - twice weekly- 1.5 h/lecture)
George Dubyak 368.5523
This is an advanced lecture/journal/discussion format course that covers cell signaling mechanisms. Includes are discussions of neurotransmitter-gated ion channels, growth factor receptor kinases, cytokine receptors, G protein-coupled receptors, steroid receptors, heterotrimeric G proteins, ras family GTPases, second messenger cascades, protein kinase cascades, second messenger regulation of transcription factors, microtubule-based motility, actin/myosin-based motility, signals for regulation of cell cycle, signals for regulation of apoptosis. (3 credits - twice weekly - 2 h/lecture)
Calvin Cotton/Corey Smith 368.4603, 368.3487
This student-guided discussion/journal course focuses on biological membranes. Topics discussed include termodynamics and kinetics of membrane transport, oxidative phosphorylation and bioenergetics, electro-physiology of excitable membranes, and whole and single channel electrophysiology, homeostasis and pH regulation, volume and calcium regulation. (3 credits - twice weekly 1.5 h/lecture)
Matthias Buck 368.8651
This course focuses on in-depth understanding of the molecular biophysics of proteins. Structural, thermodynamic and kinetic aspects of protein function and structure-function relationships will considered at the advanced conceptual level. The application of these theoretical frameworks will be illustrated with examples from the literature and integration of biophysical knowledge with description at the cellular and systems level. The format consists of lectures, problems sets, and student presentations. A special emphasis will be placed on discussion of original publications. (3 credits - twice weekly)
Ulrich Hopfer 368.2878
This course focuses on a quantitative understanding of cellular processes. It is designed for students who feel comfortable with and are interested in analytical and quantitative approaches to cell biology and cell physiology. Selected topics in cellular biophysics will be covered in depth. Topics include theory of electrical and optical signal processing used in cell physiology, thermodynamics and kinetics of enzyme and transport reactions, single ion channel kinetics and excitability, mechanotransduction, and transport across polarized cell layers. The format consists of lectures, problem sets, computer simulations, and discussion of original publications. The relevant biological background of topics will be provided appropriate for non-biology science majors. (3 credits-twice weekly)
Andrea Romani 216-368-1625
This course presents an advanced introduction to the fundamental physiological principles governing the major organ systems in mammals. The function of the nervous, endocrine, digestive, muscle, circulatory, respiratory, and urinary systems are discussed. At the conclusion of the semester, integrative aspects of the major organ systems will be illustrated through consideration of exercise and high altitude physiology. (3 credits - twice weekly - 1.5 h/lecture)
PHOL 498
Physiology and Biophysics Departmental Seminar (1)
Thomas Nosek 216-368-3242
Weekly one-hour reviews by faculty or invited speakers on their research. Students present literature reviews or summaries of their research.
PHOL 505
Laboratory of Research Rotation (3)
Thomas Nosek 216-368-3242
One-semester experience in a selected faculty research laboratory designed to introduce the student to all aspects of modern laboratory research including the design, execution, and analysis of original experimental work.
PHOL 514
Advanced Cardiovascular Physiology (3)
Andrea Romani 216-368-1625
The goal of this course is to provide the student with a solid foundation in cardiovascular physiology and pathophysiology. The course will begin by providing a solid foundation in the structure, phenotype and function of cardiac and vascular muscle. In addition, elctrophysiology and metabolism will be addressed. After covering the basic physiology, more advanced topics, such as pathophysiology, will covered using a journal club format. (3 credits - twice weekly - 1.5 hrs/class)
PHOL 517
Optical Microscopy and Imaging for Biologists
Ulrich Hopfer 216-368-2878 & A. Nieminen
This intense lecture and laboratory-based course will cover basic concepts of light microscopy and introduce advanced techniques relevant to modern cell and molecular biology. Students will gain extensive hands-on experience with state-of-the-art equipment for optical imaging guided by experienced academic instructors. The latest and most advanced instrumentation for light microscopy, image detection, and computerized image analysis will be available for us in the laboratory part of this course.
PHOL 519
Advance Pulmonary Physiology (3)
Thomas Nosek 216-368-3242
This course is designed to integrate systemic, cellular and molecular aspects of cardio-respiratory systems in physiological and pathophysiological states. The course requires prior knowledge of basic physiology of the cardiovascular systems. Extensive student participation is required. Instructors provide a brief overview of the topic followed by presentation and critical appraisal of recent scientific literature by students. (3 credits - twice weekly - 1.5 h/lecture)
PHOL 522
Special Topics in Cardiac Electrophysiology (3)
Staff 216-368-2084
Introduction to current research topics in cardiac physiology, including ionic basis for the generation of the cardiac action potential, propagation of action potentials in cardiac nerves. (3 credits)
Witold K. Surewicz 216-368-0139
This lecture/discussion/journal course focuses on techniques in the physiological sciences. Topics include spectroscopy, microscopy, and electrophysiology. The theory and practice are covered with an emphasis on examples taken from the scientific literature. (3 credits - twice weekly - 1.5 h/lecture)
PHOL 601
Research (credit as arranged)
Staff
Cellular physiology laboratory research activities that are based on faculty and student interests. (1-36 credtis)
Joseph LaManna 216-368-1112
Lecture/discussion course which explores the significance and consequences
of oxygen and oxygen metabolism in living organisms. Topics to be covered
include oxygen transport by blood tissues, oxygen toxicity, and
mitochondrial metabolism. Emphasis will be placed on mammalian physiology
with special reference to brain oxidative metabolism and blood flow as well
as whole body energy expenditure and oxidative stress related to disease. (3
credits- twice weekly - 1.5 hr/session) Permission of instructor required.
PHOL 651
Thesis (M.S.) (credit as arranged)
Staff
PHOL 701
Dissertation (Ph.D.) (credit as arranged)
Staff
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Cleveland, Ohio 44106-4970 
