John Sedor

Professor

M.D. University of Virginia, 1978
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Adhesion Structures and Regulation of Kidney Glomerular Cell Function

RESEARCH DESCRIPTION

We focus on progressive kidney disease mechanisms. The overall goal of the lab is to define the clinical, cellular and genetic bases of kidney disease in order to identify new therapies and diagnostic tests. Current projects include identification of nephropathy susceptibility genes and defining mechanisms of kidney disease progression using in vitro (cell culture) and animal models. The lab has discovered a podocyte protein that appears to critically regulate kidney filtration function (WTIP) and is now characterizing this novel protein's function and looking for mutations in its DNA sequence in families with multiple cases of kidney disease. A number of methodologic approaches are used including serial analysis of gene expression (SAGE), LC/MS and immunohistochemistry (standard and confocal imaging).

RELATED RESEARCH AREAS

View John Sedor's Publications on PubMed