Cryo-ET/EM postdoctoral position immediately available in Zhu Lab at Case Western
Reserve University
A postdoctoral position is immediately available in the Zhu Lab in the Department of
Physiology and Biophysics at Case Western Reserve University School of Medicine.
Our lab focuses on understanding the interactions between intracellular pathogens and
host cells, employing advanced microscopy techniques to investigate the in situ
structure and physiological function of antimicrobial protein complexes.
In parallel, we are also committed to advancing cryo-electron tomography (cryo-ET)
technology and exploring its applications in innate immunity. Both research areas are in
their early stages and present significant opportunities for discovery. For instance, we
have utilized cryo-ET to capture the in situ immune regulation of antimicrobial proteins
through liquid-liquid phase separation (Nature 594, 424–429, 2021) and to elucidate the
unique conformational recognition of pathogenic bacteria by immune proteins, leading
to host cell pyroptosis (Science 383, 965, 2024).
We invite highly motivated postdoctoral researchers to join our team. The lab has full
access to cutting-edge cryo-correlative light and electron microscopy (cryo-CLEM) and
an Aquilos-2 cryo-focused ion beam scanning electron microscope (cryo-FIB/SEM),
which are critical for cellular in situ cryo-ET studies. This position offers the opportunity
to develop and apply various imaging techniques, including cryo-ET and high-resolution
fluorescence microscopy, to investigate host cell defense mechanisms and pathogen
adaptation within host cells.
Candidates should hold a Ph.D. in biochemistry, biophysics, microbiology, cell biology,
or a related field. Interested applicants should email Dr. Shiwei Zhu
(shiwei.zhu@case.edu) with the following documents: A cover letter outlining research
interests and relevant experience; A current curriculum vitae (CV) and contact
information for two academic referees. We look forward to receiving your application.
