Welcome to the Department of Physiology and Biophysics!
Welcome to the Department of Physiology and Biophysics! We are over 170 faculty, fellows, students, and staff. Building on strong traditions, we strive to be a world leader in our parallel missions of research, teaching, and service. Our founding chair John Macleod was a future Nobel Laureate, Corneille Heymans was another laureate trained in the Department, and a Lasker Award winner Carl J. Wiggers chaired the Department for a generation. Our research mission benefits from a rare combination of faculty who address important translational problems in physiology and biophysics across a broad spectrum of integration—from the level of the atomic structure of molecules, through living cells and organ systems, and up to the whole organism. The major programmatic foci of our research are cardiovascular, renal, and neuronal function in health and disease. Our educational mission includes a strong PhD-training program as well as a new Master’s program in medical physiology that has attracted considerable interest. Our service mission has a strong impact at the local, national, and international levels.
Mission: research, education, service
Research Interest: integration of physiology and biophysics from atom to whole organism
Former President of FASEB, Secretary General of the IUPS, Co-director of Case’s MSTP
Co-home to textbook Medical Physiology
Welcome 2015 Masters in Medical Physiology Students
Aug. 24, 2015
The Department welcomes the Masters in Medical Physiology Class matriculating in 2015. These students come from 27 differnt states, 5 foreign countries, and 80 different colleges and universities. This is the fifth class in the MSMP program.
Congratulations to Dr. Michael Katsnelson
July 30, 2015
Michael Katsnelson, a Ph.D. candidate in the lab of Dr. George Dubyak and a student in the Medical Scientist Training Program, successfully defended his doctoral dissertation on Thursday, July 30, 2015.
The title of Dr. Katsnelson's dissertation is "Cation Channels as regulators and effectors of NLRP3 inflammasome signaling and IL-1 beta secretion".
The new Ph.D. will begin his third year in the M.D. program at the School of Medicine in the Fall semester.
A reception in Dr. Katnelson's honor was held in the afternoon after the completion of the defense.
Congratulations to Dr. Daniel Harris
July 27, 2015
Daniel Harris, a Ph.D. candidate in the lab of Dr. Paul DiCorleto, successfully defended his doctoral dissertation on Monday, July 27, 2015.
The title of Dr. Harris's dissertation is “PRMT5-Catalyzed Arginine Methylation of NF-KB p65 in the Endothelial Cell Induction of Pro-Inflammatory Chemokines”.
A reception was held in honor of the new Ph.D. after the completion of the defense.
2015 DPB Annual Retreat and Recknagel Symposium
Sept. 24, 2015
Sept. 25, 2015
The Department of Physiology and Biophysics will hold its annual retreat at the Kalahari Resort in Sandusky, OH on Thursday and Friday, September 24 and 25, 2015.
The annual Recknagel Symposium will also take place, as part of the retreat, on Friday afternoon, September 25. Six of our second year doctoral students will present on projects from their first year laboratory rotations.
Sept. 25, 2015
The Recknagel Symposium will take place, as a part of the 2015 Department Annual Retreat at the Kalihari Resort, on Friday afternoon, September 25, from 2:30 - 4:00 p.m. Six of our second year doctoral students will present on projects from their first year laboratory rotations.
During the first year of doctoral training, students in the Department rotate in three different laboratories. The goal of these rotations is to identify a subject area of interest, and a mentor for future research. After completion of the research rotations, each student presents one of the projects to the entire department in a formal setting known as The Richard Recknagel Symposium. Professor Richard Recknagel was Chairman of Physiology from 1976 to 1986. He was an admired thinker and investigator who took a keen interest in mentoring young students and faculty. In his memory, the Department established this Symposium.
1st Annual Matthew Levy Lecture
Oct. 12, 2015
The Department will host the First Annual Matthew Levy Lecture at 3:00 p.m. on Monday, October 12, 2015 in SOM Robbins E501.
The guest lecturer will be Dr. Peter Libby (image), the Mallinckrodt Professor of Medicine and a cardiovascular specialist at Harvard Medical School and Brigham and Women's Hospital.
The title of Dr. Libby's lecture is “Inflammation in Atherosclerosis –a Translational Journey”.
A pre-lecture reception will be held at 2:30 p.m. in the Department's fifth floor lobby.
Post-Bacc Application Deadline
June 15, 2016
June 15th, 2016 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program). Any online applications that have been initiated at that time will be considered even if it takes the applicant a week or so to complete the application (ex. provide your official transcript, provide GRE, MCAT, or DAT scores, provide your personal statement, provide 3 letters of recommendation). The admissions committee will review your application once it is complete and all application materials are received. If you have any questions, please contact Dr. Nosek (Thomas.Nosek@Case.edu, 216-368-3242). Contact us if you need assistance.
Annual DPB Baseball Outing
Aug. 28, 2015
The Department hosted its annual baseball outing on Friday evening, August 28, 2015.
The Cleveland Indians beat the Los Angeles Angels, 3-1, at Progressive Field.
The annual event provides a special welcome to our new students, as well as providing an enjoyable evening for other attendees from the Department. A happy hour on campus preceded the game.
Physiology & Biophysics Annual Summer Picnic
July 17, 2015
The Department hosted its annual picnic on Friday, July 17 from 3:00 - 7:00 p.m. at CWRU's Squire Valleevue Farm in Hunting Valley.
A barbecue menu was catered by A Taste of Excellence.
Congratulations to Dr. Christina Antonopoulos Buzzy and Hana Russo...
June 26, 2015
as first and second author, respectively, on acceptance of the paper, “Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling”
Christina received her Ph.D. in Pathology in December 2014, having done her doctoral research in the lab of Dr. George Dubyak. She is currently a postdoctoral scholar in the Department of Medicine in the lab of Dr. Anne Hamik, a member of the Department of Physiology and Biophysics secondary faculty.
Hana is an M.D./Ph.D. graduate student in the Pathology Ph.D. program (Immunology Track), also in the lab of Dr. George Dubyak.
J Biol Chem. 2015 Jun 22. pii: jbc.M115.652321. [Epub ahead of print]
Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR
Congratulations to Dr. Ranga Mamidi
June 22, 2015
Congratulations to Dr. Ranga Mamidi on acceptance of the paper
“Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C”
Journal of Molecular and Cellular Cardiology, 2015 (in press)
Ranganath Mamidi, Ph.D., Kenneth S. Gresham, Ami Li, Cristobal G. dos Remedios, Ph.D., Julian E. Stelzer, Ph.D.
Open House for Post-Bacc Medical Physiology Program
May 30, 2015
The Department hosted an Open House for the MS in Medical Physiology Program on Saturday, May 30th. Prospective students and family members heard all about our Masters in Medical Physiology program, toured the CWRU campus and department laboratories, and met faculty and students. Please click here for more information.
Congratulations to Peyvand Amini
May 8, 2015
Peyvand won the first place poster presentation award at the 38th Biomedical Graduate Student Symposium on May 8th, 2015.
The poster was for the project "Post-Translational Modifications of Progesterone Receptor in Human Myometrium".
Peyvand is a Ph.D. candidate in the lab of Dr. Sam Mesiano in the Department of Reproductive Biology at University Hospitals-MacDonald Women's Hospital.
Congratulations to Dr. Malcolm Hoshi
April 24, 2015
Malcolm Hoshi, a Ph.D. candidate with the lab of Dr. Isabelle Deschenes, successfully defended his Ph.D. dissertation in a public presentation on Friday, April 24, 2015.
The title of Dr. Hoshi's dissertation is “Unveiling Mechanisms Involved in Non-Traditional Cases of Inherited Cardiac Channelopathies”.
A reception was held following the public defense.
Third Annual Ulrich Hopfer Lecture
April 22, 2015
The Department of Physiology and Biophysics hosted the Third Annual Ulrich Hopfer Lecture on Wednesday, April 22, 2015.
The guest lecturer was Dr. Richard Johnson of the University of Colorado Anschutz Medical Campus in Aurora, CO.
Dr. Johnson's lecture was entitled “Fructose and its Role in Obesity and Metabolic Syndrome”.
Congratulations to Dr. Ranganath Mamidi
April 17, 2015
Dr. Ranga Mamidi, a Postdoctoral Scholar in the lab of Dr. Julian Stelzer, won the Postdoctoral Research Award for his poster presentation at the 2015 Research ShowCASE.
Dr. Mamidi won the same award at the 2014 Research ShowCASE.
Congratulations to Michael Katsnelson and Hana Russo
April 10, 2015
The manuscript “K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling”, submitted by Michael Katsnelson and Hana Russo, has been accepted for publication by the Journal of Immunology.
Michael and Hana are MD/PhD candidates in the Medical Sciences Training Program in Pathology (Immunology Track) and are in the lab of Dr. George Dubyak.
J Immunol., 2015 Apr 15; 194(8):3937-52. doi: 10.4049/jimmunol.1402658. Epub 2015 Mar 11.
Michael A. Katsnelson, L. Graham Rucker, Hana M. Russo, and George R. Dubyak
Welcome postdoc Saketh Chemuru Muni
March 16, 2015
Saketh joined the lab of Dr. Witold Surewicz as a postdoctoral scholar, effective March 16, 2015.