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Welcome to the Department of Physiology and Biophysics!

Welcome to the Department of Physiology and Biophysics! We are over 170 faculty, fellows, students, and staff. Building on strong traditions, we strive to be a world leader in our parallel missions of research, teaching, and service. Our founding chair John Macleod was a future Nobel Laureate, Corneille Heymans was another laureate trained in the Department, and a Lasker Award winner Carl J. Wiggers chaired the Department for a generation. Our research mission benefits from a rare combination of faculty who address important translational problems in physiology and biophysics across a broad spectrum of integration—from the level of the atomic structure of molecules, through living cells and organ systems, and up to the whole organism. The major programmatic foci of our research are cardiovascular, renal, and neuronal function in health and disease. Our educational mission includes a strong PhD-training program as well as a new Master’s program in medical physiology that has attracted considerable interest. Our service mission has a strong impact at the local, national, and international levels.

  • Mission: research, education, service
  • Research Interest: integration of physiology and biophysics from atom to whole organism
  • Former President of FASEB, Secretary General of the IUPS, Co-director of Case’s MSTP
  • Co-home to textbook Medical Physiology

Welcome 2015 Masters in Medical Physiology Students

Aug. 24, 2015

The Department welcomes the Masters in Medical Physiology Class matriculating in 2015. These students come from 27 differnt states, 5 foreign countries, and 80 different colleges and universities. This is the fifth class in the MSMP program.

Welcome postdoc Mukesh Mahajan

Sept. 10, 2015

Mukesh Mahajan, PhD. joined the lab of Dr. Matthias Buck as a postdoctoral scholar, effective September 10, 2015.

1st Annual Matthew Levy Lecture

Oct. 12, 2015 3 p.m. - 4 p.m.

The Department will host the First Annual Matthew Levy Lecture at 3:00 p.m. on Monday, October 12, 2015 in SOM Robbins E501.

The guest lecturer will be Dr. Peter Libby (image), the Mallinckrodt Professor of Medicine and a cardiovascular specialist at Harvard Medical School and Brigham and Women's Hospital.


The title of Dr. Libby's lecture is “Inflammation in Atherosclerosis –a Translational Journey”.

A pre-lecture reception will be held at 2:30 p.m. in the Department's fifth floor lobby.

Congratulations to Dr. Rossana Occhipinti

Sept. 18, 2015

Congratulations to Rossana Occhipinti, Ph.D. on the award of a K01 grant from the National Institute of Diabetes and Digestive and Kidney Diseases for the project:

"Acid secretion and intracellular pH regulation in proximal-tubule cells"

The award was effective on September 18, 2015 and the project will run through August 31, 2020.

Upcoming News/Events

Post-Bacc Application Deadline

June 15, 2016

June 15th, 2016 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program). Any online applications that have been initiated at that time will be considered even if it takes the applicant a week or so to complete the application (ex. provide your official transcript, provide GRE, MCAT, or DAT scores, provide your personal statement, provide 3 letters of recommendation).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (, 216-368-3242). Contact us if you need assistance.

Recent News/Events

Recknagel Symposium

Sept. 25, 2015 2:30 p.m. - 4 p.m.

The Recknagel Symposium will take place, as a part of the 2015 Department Annual Retreat at the Kalihari Resort, on Friday afternoon, September 25, from 2:30 - 4:00 p.m. Six of our second year doctoral students will present on projects from their first year laboratory rotations.

During the first year of doctoral training, students in the Department rotate in three different laboratories. The goal of these rotations is to identify a subject area of interest, and a mentor for future research. After completion of the research rotations, each student presents one of the projects to the entire department in a formal setting known as The Richard Recknagel Symposium. Professor Richard Recknagel was Chairman of Physiology from 1976 to 1986. He was an admired thinker and investigator who took a keen interest in mentoring young students and faculty. In his memory, the Department established this Symposium.

2015 DPB Annual Retreat and Recknagel Symposium

Sept. 24, 2015 - Sept. 25, 2015

The Department of Physiology and Biophysics will hold its annual retreat at the Kalahari Resort in Sandusky, OH on Thursday and Friday, September 24 and 25, 2015.

The annual Recknagel Symposium will also take place, as part of the retreat, on Friday afternoon, September 25. Six of our second year doctoral students will present on projects from their first year laboratory rotations.

Annual DPB Baseball Outing

Aug. 28, 2015 7:10 p.m.

The Department hosted its annual baseball outing on Friday evening, August 28, 2015.

The Cleveland Indians beat the Los Angeles Angels, 3-1, at Progressive Field.

The annual event provides a special welcome to our new students, as well as providing an enjoyable evening for other attendees from the Department. A happy hour on campus preceded the game.

Congratulations to Dr. Michael Katsnelson

July 30, 2015

Michael Katsnelson, a Ph.D. candidate in the lab of Dr. George Dubyak and a student in the Medical Scientist Training Program, successfully defended his doctoral dissertation on Thursday, July 30, 2015.

The title of Dr. Katsnelson's dissertation is "Cation Channels as regulators and effectors of NLRP3 inflammasome signaling and IL-1 beta secretion".

The new Ph.D. will begin his third year in the M.D. program at the School of Medicine in the Fall semester.

A reception in Dr. Katnelson's honor was held in the afternoon after the completion of the defense.

Congratulations to Dr. Daniel Harris

July 27, 2015

Daniel Harris, a Ph.D. candidate in the lab of Dr. Paul DiCorleto, successfully defended his doctoral dissertation on Monday, July 27, 2015.

The title of Dr. Harris's dissertation is “PRMT5-Catalyzed Arginine Methylation of NF-KB p65 in the Endothelial Cell Induction of Pro-Inflammatory Chemokines”.

A reception was held in honor of the new Ph.D. after the completion of the defense.

Physiology & Biophysics Annual Summer Picnic

July 17, 2015 3 p.m. - 7 p.m.

The Department hosted its annual picnic on Friday, July 17 from 3:00 - 7:00 p.m. at CWRU's Squire Valleevue Farm in Hunting Valley.

A barbecue menu was catered by A Taste of Excellence.

Congratulations to Dr. Christina Antonopoulos Buzzy and Hana Russo...

June 26, 2015

as first and second author, respectively, on acceptance of the paper, “Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling”

Christina received her Ph.D. in Pathology in December 2014, having done her doctoral research in the lab of Dr. George Dubyak.  She is currently a postdoctoral scholar in the Department of Medicine in the lab of Dr. Anne Hamik, a member of the Department of Physiology and Biophysics secondary faculty.

Hana is an M.D./Ph.D. graduate student in the Pathology Ph.D. program (Immunology Track), also in the lab of Dr. George Dubyak.

 J Biol Chem. 2015 Jun 22. pii: jbc.M115.652321. [Epub ahead of print]

Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR

Congratulations to Dr. Ranga Mamidi

June 22, 2015

Congratulations to Dr. Ranga Mamidi on acceptance of the paper

“Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C”

Journal of Molecular and Cellular Cardiology, 2015 (in press)


Ranganath Mamidi, Ph.D., Kenneth S. Gresham, Ami Li, Cristobal G. dos Remedios, Ph.D., Julian E. Stelzer, Ph.D.

Open House for Post-Bacc Medical Physiology Program

May 30, 2015

The Department hosted an Open House for the MS in Medical Physiology Program on Saturday, May 30th.  Prospective students and family members heard all about our Masters in Medical Physiology program, toured the CWRU campus and department laboratories, and met faculty and students. Please click here for more information.

Congratulations to Peyvand Amini

May 8, 2015

Peyvand won the first place poster presentation award at the 38th Biomedical Graduate Student Symposium on May 8th, 2015.

The poster was for the project "Post-Translational Modifications of Progesterone Receptor in Human Myometrium".

Peyvand is a Ph.D. candidate in the lab of Dr. Sam Mesiano in the Department of Reproductive Biology at University Hospitals-MacDonald Women's Hospital.

Congratulations to Dr. Malcolm Hoshi

April 24, 2015

Malcolm Hoshi, a Ph.D. candidate with the lab of Dr. Isabelle Deschenes, successfully defended his Ph.D. dissertation in a public presentation on Friday, April 24, 2015.

The title of Dr. Hoshi's dissertation is “Unveiling Mechanisms Involved in Non-Traditional Cases of Inherited Cardiac Channelopathies”.

A reception was held following the public defense.

Third Annual Ulrich Hopfer Lecture

April 22, 2015 4 p.m.

The Department of Physiology and Biophysics hosted the Third Annual Ulrich Hopfer Lecture on Wednesday, April 22, 2015.

The guest lecturer was Dr. Richard Johnson of the University of Colorado Anschutz Medical Campus in Aurora, CO.

Dr. Johnson's lecture was entitled “Fructose and its Role in Obesity and Metabolic Syndrome”.


Congratulations to Dr. Ranganath Mamidi

April 17, 2015

Dr. Ranga Mamidi, a Postdoctoral Scholar in the lab of Dr. Julian Stelzer, won the Postdoctoral Research Award for his poster presentation at the 2015 Research ShowCASE.

Dr. Mamidi won the same award at the 2014 Research ShowCASE.

Post-Baccalaureate Program MS in Medical Physiology

PhD Program Physiology and Biophysics

Upcoming Seminars


"Inflammation in Atherosclerosis –a Translational Journey"

Peter Libby, MD
Oct. 12, 2015 3 p.m. - 4 p.m.

School of Medicine E501
Hosted by: Mukesh K. Jain, MD


"N-glycan directed folding and quality control in the ER"

Daniel N. Hebert, PhD
Oct. 19, 2015 4 p.m. - 5 p.m.

School of Medicine E501
Hosted by: Tingwei Mu, PhD


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